Connective Tissue Growth Factor

Catalog#	Product Description	Host Species	Nature	Cross reactivity	Quantity	Volume	Price
CTGF-101AP	Affinity Purifed CTGF antibodies	Rabbit	AP	r, m, h, others	100.0 ug	150-500 ul	$245.00
FITC-CTGF	FITC-conjugated CTGF antibodies	Rabbit	FITC-AP	r, m, h, others	100.0 ug	150-500 ul	$350.00
P-CTGF	Antigenic blocking peptide for CTGF	n/a	Synthetic peptide	n/a	250.0 ug	100 ul	$125.00
PC-CTGF	WB positive control for CTGF	n/a	Protein in ready-to-use buffer	n/a	0.0 ug	150 ul	$185.00

Connective tissue growth factor (CTGF) belongs to the CCN family of proteins (1). CTGF is also related to platelet-derived growth factor; it is a cystein-rich pro-adhesive protein that plays an essential role in cell adhesion, chondrocyte proliferation and differentiation, and in the formation of blood vessels and connective tissue (2). CTGF expression was shown to be induced by TGF-beta and it has been suggested that CTGF mediates several downstream actions of TGF-beta (3). CTGF plays a critical role in Angiotensin II-mediated hypertensive nephropathy. This protein was in fact activated by Angiotensin II via TGF-beta-dependent and –independent Smad3 signaling pathways (4). Expression of CTGF is absent in normal adult skin, it is only during the wound healing response that this protein is overexpressed in the fibroblasts in fibrotic lesions (5). Therefore, this protein is also required for muscle repair and fibrosis.

The overexpression of CTGF in fibrotic lesions has been shown to contribute to the phenotype of systemic sclerosis. Furthermore, variations in this protein are also linked with systemic sclerosis (6). Expression of CTGF protein was also shown to significantly increase when cultured human renal tubular epithelial cells were subjected to a high glucose treatment, and overexpression of CTGF was found in the muscles of patients with muscular dystrophy (7). CTGF is located on human chromosome 6q23.1. It is expressed in skeletal muscle, bone marrow and thymic cells. In human and mouse, CTGF is approximately a 42kDa protein (349 amino acids). In rats, it is a 57.1kDa protein (476 amino acids).

The CTGF antibodies were generated using peptide corresponding to human CTGF protein. CTGF antibodies are affinity purified over immobilized antigen based affinity chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc. will provide limited quantities of antigenic blocking protein for competition assays involving CTGF antibodies. Antibodies to CTGF (CTGF-101AP) will label ~57.1kDa protein in Western blot positive control for CTGF (PC-CTGF) and several other tissues. FabGennix Inc. will conjugate this and other antibodies from its catalog to either secondary enzymes (alk-Pase or HRP) or fluorescent probes at a nominal cost upon request. FabGennix also provides custom antibody production services for researchers that are looking for high affinity mono and polyclonal antibodies in various species. We specialize in making application specific antibodies that are useful in IHC, confocal and other applications where native antigen is detected.

For research use only, not for diagnostic or therapeutic use.

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Connective Tissue Growth Factor

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