Norepinephrin Transporter
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| NET-101AP | Norepinephrin Transporter antibodies | Rabbit | AP | r, m, h | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-NET | FITC-conjugated antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 150-500 ul |
$350.00
|
| P-NET | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-NET | WB positive control for NET | n/a | Protein | n/a | 0.0 ug | 150 ul |
$185.00
|
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atecholamine, a term used for hormones epinephrine (E) and its sequentially hydroxylated form, Nor epinephrine (NE) are involved in fight or flight responses. NE is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release (1). In CNS, NE is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors and control of endocrine and autonomic nervous system. Peripherally, NE is present in sympathetic nerve endings and have full control of sympathetic nervous system. The released NE from pre synaptic nerve terminals is re absorbed (70-90%) by Nor-epinephrine transporters (NET) and its biological effects are terminated. The NE transport via NET is an active, Na+/Cl- dependent- transport process mediated by NET (2). NETs constitute the primary mechanism for inactivation of synaptically released NE, are targets for multiple antidepressants and psycho stimulants, and are deficient in affective and autonomic disorders. In rat brain, NET is expressed in noradrenergic neuronal somata, axons, and dendrites, and hippocampus and cortex, but was absent from epinephrine- and dopamine-containing neurons (3).
At least 13 genetic variations have been reported in the NET protein (3) that affect NE re-uptake and concentrations in cerebrospinal fluid in humans. The association between these genetic variations in NET and several psychiatric and cardiovascular disorders are just emerging (1, 4). Recently, single amino acid mutation (hNET-A457P) showed deficiency in NE transport in a orthostatic intolerance patient (5). NET protein consists of 617 amino acids and has 12 trans-membrane domains, a characteristic feature of many membrane associated solute transporters. Our NET (NET-100P and NET-101AP) antibodies label a 85kDa protein in our western blot positive control samples.
The NET-1-selective antibodies were generated against unique N-terminal peptide that are unique to NET-1 protein. FabGennix Inc. has generated specific antibodies to various other transporter proteins. These antibodies are raised utilizing linear, multiple antigenic peptides or cyclic peptide methodology. The NET antibodies are characterized by. The NET antibodies have been fully characterized (ELISA, WB, immunoprecipitation protocol) for their cross reactivity with other members of transporter family. FabGennix Inc. has produced antibodies to multiple epitopes on the same protein, thus allows a detailed characterization of physiological role of various functional domains on protein.
For research use only, not for diagnostic or therapeutic use.
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