Mammalian Gene Clone 13057
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| C2Orf88-101AP | C2Orf88 N-epitope Ab | Rabbit | Affinity purified | h | 100.0 ug | 200 ul |
$245.00
|
| C2Orf88-112AP | C2Orf88 ( Mid-Region epitope) Ab | Rabbit | Affinity purified | h | 100.0 ug | 200 ul |
$245.00
|
| C2Orf88-121AP | C2Orf88 (Near C-terminal epitope) Ab | Rabbit | Affinity purified | h | 100.0 ug | 200 ul |
$245.00
|
| FITC-C2Orf88.1 | FITC-conjugated N-terminal C2Orf88-101AP | Rabbit | FITC-conjugated antibodies | h | 100.0 ug | 200 ul |
$350.00
|
| FITC-C2Orf88.2 | FITC-conjugated Mid-regionC2Orf88-112AP | Rabbit | FITC-conjugated antibodies | h | 100.0 ug | 200 ul |
$350.00
|
| FITC-C2Orf88.3 | FITC-conjugated C-terminal C2Orf88-121AP | Rabbit | FITC-conjugated antibodies | h | 100.0 ug | 200 ul |
$350.00
|
| P-MGC13057.1 | N-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-MGC13057.2 | Mid-region antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-MGC13057.3 | C-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-MGC13057 | WB positive control for MGC13057 | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
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he National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones for an additional 7,800 human and 3,500 mouse genes also have been identified. All MGC sequences and clones are available without restriction through public databases and clone distribution networks (1).
Certain loci on human chromosome 17q12 are frequently amplified in various types of cancers. One of such loci is PP1R1B-ERBB2-GRB7 which is greatly amplified in gastric and breast cancer. Search of other genes that reside close to this recombination hot spot or “fragile loci” led to discovery of several genes, one of these genes is a new theoretical protein MGC13057 is localized on chromosome 17 at cytogenetic location of 17q21.2. The detailed analyses of the amplicon structure in 330 breast tumors samples revealed a 280 kb common region of amplification that contains 10 genes that include 8 known genes. A highly significant association between amplification and expression levels was observed for 6 genes including ERBB2 and 3 uncharacterized hypothetical proteins, MGC13057, MGC9753 and MGC14832 in breast carcinoma and human gastric cancer samples (1, 2).
The MGC13057 is a 95 amino acid uncharacterized protein. The MGC-13057-selective antibodies were generated in rabbits against unique N, mid-region and C-terminal peptides that are unique to MGC13057 protein. FabGennix Inc. has generated specific rabbit anti-MGC13057 polyclonal (mono-epitope-specific) antibodies utilizing linear or cyclic peptide sequences. These antibodies have been characterized for cross-reactivity with other members of the amplicon related proteins. FabGennix Inc. has produced antibodies to multiple epitopes on the same protein that will facilitate studies utilizing epitope analyses and other functional and interspecies cross reactivity. FabGennix Inc. also provides limited quantities of antigenic blocking peptides for MGC13057 antibodies.
For research use only, not for diagnostic or therapeutic use.
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