Mammalian Gene Clone 14832
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| XTP4-101AP | XTP4 N-terminal antibodies | Rabbit | AP | r, m, h | 100.0 ug | 200ul |
$245.00
|
| XTP4-112AP | XTP4 Mid-region antibodies | Rabbit | AP | r, m, h | 100.0 ug | 200 ul |
$245.00
|
| XTP4-121AP | XTP4 C-terminal antibodies | Rabbit | AP | r, m, h | 100.0 ug | 200 ul |
$245.00
|
| XTP4-131AP | XTP4 C-terminal antibodies | Rabbit | AP | r, m, h | 100.0 ug | 200 ul |
$245.00
|
| FITC-XTP4-101 | FITC-conjugated N-terminal XTP4 antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 200 ul |
$350.00
|
| FITC-XTP4-112 | FITC-conjugated mid-region XTP4 antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 200 ul |
$350.00
|
| FITC-XTP4-121 | FITC-conjugated C-terminal XTP4 antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 200 ul |
$350.00
|
| FITC-XTP4-131 | FITC-conjugated C-terminal XTP4 antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 200 ul |
$350.00
|
| P-XTP4-101 | N-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-XTP4-112 | Mid-region antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-XTP4-121 | C-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-XTP4-131 | C-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-XTP4 | WB positive control for XTP4 antibodies | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
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C
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ertain loci on human chromosome 17q12 are frequently amplified in various types of cancers. One of such loci is PP1R1B-ERBB2-GRB7 which is greatly amplified in gastric and breast cancer. Search of other genes that reside close to this recombination hot spot or “fragile loci” led to discovery of several genes, one of these genes is a new theoretical protein MGC14832 is localized on chromosome 17 at cytogenetic location of 17q21.2. The detailed analyses of the amplicon structure in 330 breast tumors samples revealed a 280 kb common region of amplification that contains 10 genes that include 8 known genes. A highly significant association between amplification and expression levels was observed for 6 genes including ERBB2 and 2 uncharacterized hypothetical proteins, MGC9753 and MGC14832 in breast carcinoma and human gastric cancer samples (1, 2).
MGC14832 is located on human chromosome 17q12 and is in the amplicon cluster consist of PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 with in the 120 kb region locus on human chromosome 17q12. The XTP4-selective antibodies were generated in rabbits against unique N, mid-region and C-terminal peptides that are unique to MGC14832 protein. FabGennix Inc. has generated specific rabbit anti-MGC14832 polyclonal mono-epitope-specific antibodies utilizing linear or cyclic peptide sequences. These antibodies have been fully characterized for cross-reactivity with other members of the amplicon related proteins. FabGennix Inc. has produced antibodies to multiple epitopes on the same protein that will facilitate studies utilizing epitope analyses and other functional and interspecies cross reactivity. FabGennix Inc. also provides limited quantities of antigenic blocking peptides for MGC14832 antibodies.
For research use only, not for diagnostic or therapeutic use.
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