Disrupted in Schizophrenia 1
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| DISC1-101AP | DISC1 antibodies | Rabbit | AP | h | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-DISC1 | FITC-conjugated antibodies | Rabbit | FITC-AP | h | 100.0 ug | 150-500 ul |
$350.00
|
| P-DISC1 | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-DISC1 | WB positive control for DISC1 | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
The genetic and epidemiological studies suggest that schizophrenia is largely due to individual variation and susceptibility of different alleles with small to moderate effects on multiple genes. Molecular genetic studies have identified several potential regions of linkage and 2 associated chromosomal abnormalities in Schizophrenia and suggest several positional candidate genes including Disrupted in Schizophrenia 1 (DISC1). DISC1 is linked to Schizophrenia by association and linkage studies in independent population and is the only gene whole open reading frame (ORF) is truncated and co segregates with mojor mental illnesses in a Scottish population. It is well known that several neuronal pathways are disrupted in schizophrenia, the complexity of the genetics underlying schizophrenia is highlighted by the multitude of molecular pathways that have been reported to be disrupted in the disorder including muscarinic, serotonergic, and glutamatergic signaling systems. The genetic and epidemiological studies suggest that schizophrenia is largely due to individual variation and susceptibility of different alleles with small to moderate effects on multiple genes. Molecular genetic studies have identified several potential regions of linkage and 2 associated chromosomal abnormalities in Schizophrenia and suggest several positional candidate genes including Disrupted in Schizophrenia 1 (DISC1). Recent epigenetic and molecular biology data strongly suggest Disrupted in Schizophrenia 1 (Disc 1) gene as a risk factor of great significance in the underlying causes of Schizophrenia and related disorders. No functional significance of this protein was evident despite the presence of several well characterized protein domains on Disc 1. Recently the discovery and identification of its binding partners has revealed an incredible diversity of potential cellular and physiological functions. The interactive yeast-two hybrid screening revealed the “Disc 1 interactome” which contained several novel protein-protein interaction sites suggesting its role in several diverse functions. Studies on Disc 1 interactome showed protein-protein interaction with ligands that are consistent with the underlying molecular pathology observed at the synaptic level and the cognitive deficits seen behaviorally in schizophrenics (1). Phosphodiesterase Type 4B (PDE4B) and Ndell-EOPA are two known target proteins that actively interact with Disc 1 (2).
The genetic and epidemiological studies suggest that schizophrenia is largely due to individual variation and susceptibility of different alleles with small to maderate effects on multiple genes. Molecular genetic studies have identified several potential regions of linkage and 2 associated chromosomal abnormalities in Schizophrenia and suggest several positional candidate genes including Disrupted in Schizophrenia 1 (DISC1). DISC1 is linked to Schizophrenia by association and linkage studies in independent population and is the only gene whole open reading frame (ORF) is truncated and co segregates with major mental illnesses in a Scottish population. A recent attempt to study and localize DISC1 in human autopsied brain samples from patients with schizophrenia, bipolar disorder, and major depression. GenerallyDISC1 is localized in nucleus of HeLa cells, however, this localization was altered in orbitofrontal cortex significantly in all major mental illnesses including substance and alcohol abuse suggesting DISC1 may be implicated in psychiatric conditions (1). Disc1 transgenic mice displayed several behavioral abnormalities including hyperactivity, disturbance in sensorimotor gating and olfactory and olfactory-associated behaviors and anhedonia and depression like symptoms (2). Several single nucleotide polymorphisms (SNPs) in DISC1 gene were typed, a three-SNP halotype spanning 83 kb of the gene was associated with schizophrenia in family-based sample 93). Disc 1 was found in hippocampus where allelic variation in Disc 1at Ser704Cys would have measurable impact on hippcampal structure and function including reduced hippocampal gray matter volume and altered engagement of hippocampus during several cognitive tasks assays (3). Disc1 is 832 amino acid protein with predicted MW of around 100kDa. In brain Disc1 is expressed as two distinct bands of molecular weight 95-100kDa and 70-85 kDa in human brain. This patters is similar in rodent brain where 70-85kDa band intensity is much more intense than higher MW species. The identity of the 70-85 kDa species is still not yet confirmed.
The Disc1-selective antibodies were generated against unique antigenic sequence form near C-terminal end (aa ) of the Disc1gene. The antibodies to Disc1are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc., will also provide limited quantities of antigenic blocking peptides for Disc1-101AP. Antibodies to Disc1 (Disc1-101AP) will label 100kDa and shorter form of Disc1 in PC-Disc1 samples. FabGennix Int. Inc., have made several other Alzheimer’s-related target antibodies which are now available from FabGennix International Inc. For a complete listings visit www.FabGennix.com. FabGennix Inc. will also conjugate antibodies with secondary enzymes (alk-Pase or HRP) or fluorescent probes upon request at a nominal cost.
For research use only, not for diagnostic or therapeutic use.
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