Baboon Antibodies

Transmembrane receptor Patched regulates several developmental processes in both invertebrate and vertebrates.  In higher vertebrates the patched (Ptc) also acts as tumor suppressor.  The patched receptor signaling involves negatively regulating a GPCR, smoothened.  The binding Hedgehog ligand to Ptc, removes the negative interaction of Ptc and allows the signaling by smoothened.  It has been shown that Ptc D. melanogasater head development.  During head morphogenesis in D. melanogaster Ptc positively interacts with smoothened, which leads to stimulation of Activin type 1 receptor Baboon and activation of cell proliferation in the eye-antennal disc (3).  The expression of activated Baboon in the Ptc domain in Ptc mutant background completely abolish the head developmental defects. 

Baboon is a 601 amino acid long (Mr. Wt. 73 kDa) protein with a single transmembrane domain.  FabGennix International Inc. has produced epitope specific anti-Baboon antibodies in rabbit.  The Anti-Baboon-selective antibodies were generated against a peptide sequence near the C-terminal end of the protein that are unique to Baboon protein.  The Baboon-selective antibodies are affinity purified against immobilized antigen based affinity chromatography which yielded epitope-specific antibodies.  The Baboon antibodies label a 73-74 kDa protein in D. melanogaster extracts.  Anti-Baboon-selective antibodies are also available in affinity-purified form for confocal, Western blotting and immunocytochemical analyses.  FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge.   FabGennix Inc. also provides several antibodies against proteins that are involved in Drosophila melanogaster research such as several Anti-PDE antibodies, Anti-Tkv, Anti-Wishful thinking, Anti-Baboon, Anti-Shadow, Anti-Shade, Anti-SARA anchor protein, Anti-Phantom and Anti-Saxophone protein.  FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6).  FabGennix, Inc., will also provide Western blot positive controls for most of these antibodies in ready-to-use buffer for easy identification of respective proteins.  Limited quantities of antigens are also available.  Please enquire for their availability before ordering.

For research use only, not for diagnostic or therapeutic use.