HDCMA18P/CD13 antibody

The RNA recognition motif, also known as RNA binding motif, is probably diagnostic of an RNA binding protein.  RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs.  The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases. There is a second region towards the C terminus that has some features of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main auto antigens in Systemic lupus.  The APN2 protein was recently sequences under mammalian gene cloning project (MGC).  This clone was sequences because it matches with the complete sequence of mRNA corresponding to gi: 7705400.

The APN2 (HDCMA18P) is a soluble protein with several structural motifs at the N-terminal end of the protein including a La protein interaction site and a strong RRM regions.  The protein is also involves in signal transduction leading to malignant signals.  The 77-79 kDa APN2 protein is generally express in detectable quantities in various cell lines and malignant tissues. 

The Anti-APN2-selective antibodies were generated in rabbits against unique epitopes that reside on the surface of the protein.  The APN2 epitope corresponds to 255-271 aa on the APN2 gene.  FabGennix Inc. has generated specific rabbit anti-APN2 antibodies using linear and post-translationaly modified  peptide methodology.  These antibodies have been characterized by ELISA and dot blot assays using various cancer cell lines.  FabGennix Inc. has also produced other elated antibodies that will facilitate breast and other type of cancer detection.  These antibodies include Anti-SERHL, Anti-mucin, Anti-p14arf, Anti-src, Anti-Ras, Anti-CAB2, Anti-XTP4 and others.  For a complete listing please visit our website at www.FabGennix.com.   FabGennix Inc. also provides limited quantities of antigenic blocking peptides for APN2 antibodies.