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Serine Hyrolase1

Catalog# Product Description Host Species Nature Cross reactivity Quantity Volume Price
SERHL-101AP SERHL N-terminal antibodies Rabbit AP H 100.0 ug 150-500 ul $245.00
SERHL-112AP SERHL mid-region antibodies Rabbit AP H 100.0 ug 150-500 ul $245.00
SERHL-121AP SERHL C-terminal antibodies Rabbit AP H 100.0 ug 150-500 ul $245.00
FITC-SERHL100 FITC-conjugated N-terminal antibodies Rabbit FITC-AP H 100.0 ug 150-500 ul $350.00
FITC-SERHL110 FITC-conjugated mid-region antibodies Rabbit FITC-AP H 100.0 ug 150-500 ul $350.00
FITC-SERHL120 FITC-conjugated C-terminal antibodies Rabbit FITC-AP H 100.0 ug 150-500 ul $350.00
P-SERHL101 N-terminal antigenic blocking peptide n/a Synthetic peptide n/a 250.0 ug 100 ul $125.00
P-SERHL112 Mid-region antigenic blocking peptide n/a Synthetic peptide n/a 250.0 ug 100 ul $125.00
P-SERHL121 C-terminal antigenic blocking peptide n/a Synthetic peptide n/a 250.0 ug 100 ul $125.00
PC-SERHL WB positive control for SERHL n/a Protein in ready-to-use buffer n/a 0.0 lb 150 ul $185.00
Muscular hypertrophy is generally associated with extended period of passive muscle stretch which is associated with increased mRNA and protein synthesis. There are several hypertrophic agonist have been identified as probable candidates for such muscle anabolic effects. However, little is known as to how the mechanical exercise is converted in to intracellular signals regulating gene expression resulting in an increase in cell size and is regarded as a beneficial adaptive response to increased exercise/workload, but in some instances hypertrophy can be detrimental as seen in long-term cardiac hypertrophy. On the other hand, muscle wasting, muscle atrophy, is a feature of both inherited and acquired muscle disease and also as normal aging processes. Certain genes were identified by substractive mRNA hybridization prepared from passively stretched and control murine skeletal muscle. One of the mRNA that undergoes increased expression in response to passive stretch codes for one RNA that is significantly increased in passively stretched muscle. Encoded within the mRNA is an open reading frame of 311 amino acids (38 kDa) containing a highly conserved type 1 peroxisomal targeting signal and a serine lipase active center. The sequence shows identity to a family of serine hydrolases and thus is named serine hydrolase-like (Serhl) or karaken-like. There are 2 SERHL variants identified, SERHL1 and SERHL2, both are ubiquitously present, in higher amounts in kidney and skeletal muscle. The predicted three-dimensional structure displays a core alpha/beta-hydrolase fold and  catalytic triad characteristic of several hydrolytic enzymes. 
SERHL is located on human chromosome 22q13 (2) encoded by 5 exons and most likely have splice variants. This protein is a cytoplasic protein that is concentrated in perinuclear vesicvles and based on sequence similarity may be associated with peoxisomes. SERHL1 and SERHL2 are believed to play an important role in skeletal muscle development and peroxisome function in response to mechanical stimuli. Both SERHL1 and SERHL2 are ubiquitously present, high expression is noted in kidney, skeletal muscle and large intestine. Endogenous expression of SERHL 1 is localized to perinuclear vesicles (1). 
The SERHL-1-selective antibodies were generated in rabbits against unique N, mid-region and C-terminal peptides that are unique to SERHL1 protein.  FabGennix Inc. has generated specific rabbit anti-serine hydrolase like (SERHL1) polyclonal mono-epitope-specific antibodies utilizing linear or cyclic peptide sequences. These antibodies have been fully characterized for cross reactivity with other members of the serine hydrolase proteins. FabGennix Inc. has produced antibodies to multiple epitopes on the same protein that will facilitate studies utilizing epitope analyses and other functional and interspecies cross reactivity.  FabGennix Inc. also provides limited quantities of antigenic blocking peptides for SERHL1 antibodies.

For research use only, not for diagnostic or therapeutic use.

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Serine Hydrolase 1

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