Secreted frizziled-related protein 5

Catalog#	Product Description	Host Species	Nature	Cross reactivity	Quantity	Volume	Price
Sfrp5-501AP	Affinity Purified Sfrp5 antibodies	Rabbit	AP	r, m, h, others	100.0 ug	150-500 ul	$245.00
FITC-Sfrp5	FITC-conjugated Sfrp5 antibodies	Rabbit	FITC-AP	r, m, h, others	100.0 ug	150-500 ul	$350.00
P-Sfrp5	Antigenic blocking peptide for Sfrp5	n/a	Synthetic peptide	n/a	250.0 ug	100 ul	$125.00
PC-Sfrp5	WB positive control for Sfrp5	n/a	Protein in ready-to-use buffer	n/a	0.0 ug	150 ul	$185.00

Secreted frizziled-related protein 2 (Sfrp2) is a member of Sfrp family of proteins, consisting of five members in mammals. The N-terminal region of these proteins shares sequence homology with extracellular Wnt binding domain of frizziled receptors (1). Wnts are a large family of cysteine-rich secreted glycoproteins that control development in various organisms (2). Since Sfrp family of proteins interact directly with Wnts, the Sfrp family of proteins have also been implicated in early embryonic development as well as modulating apoptotic events (3). More specifically, sfrp5 is implicated in determining the polarity of photoreceptor cells in the retina (4). Furthermore, it is an anti-inflammatory adipokine (5). Sfrp5 is a promising target in cancer treatment because it is known to play an important role in the development of bladder tumor and its downregulation or overexpression is linked with various cancers (6).

Hypermethylation of the promoter region of sfrp5 deactivates this protein, this leads to oncogenic activation of wnt signaling pathway which is common in cancers (7). Therfore, inactivation of sfrp5 has been linked with oral squamous cell carcinoma, ovarian and colorectal cancers (8). Hypermethylation, as well as overexpression of sfrp5 was reported to be seen in pancreatic cancers (9). Sfrp5 is located on human chromosome 10q24.1. It is highly expressed in retinal pigment epithelium. It is also expressed in pancreas and weakly expressed in heart, liver and skeletal muscle. Sfrp5 is approximately a 38kDa protein (317 amino acids).

The Sfrp5 antibodies were generated using peptide corresponding to human Sfrp5 protein. Sfrp5 antibodies are affinity purified over immobilized antigen based affinity chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc. will provide limited quantities of antigenic blocking protein for competition assays involving Sfrp5 antibodies. Antibodies to Sfrp5 (Sfrp5-501AP) will label ~38kDa protein in Western blot positive control for Sfrp5 (PC-Sfrp5) and several other tissues. FabGennix Inc. will conjugate this and other antibodies from its catalog to either secondary enzymes (alk-Pase or HRP) or fluorescent probes at a nominal cost upon request. FabGennix also provides custom antibody production services for researchers that are looking for high affinity mono and polyclonal antibodies in various species. We specialize in making application specific antibodies that are useful in IHC, confocal and other applications where native antigen is detected.

For research use only, not for diagnostic or therapeutic use.

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Secreted frizziled-related protein 5

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