Presenilin2
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| PSEN-201AP | Presenilin2 antibodies | Rabbit | AP | r, m, h | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-PSEN2 | FITC-conjugated antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 150-500 ul |
$350.00
|
| P-PSEN2 | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-PSEN2 | WB positive control for PSEN2 | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
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n Alzheimer’s disease (AD) a progressive neurodegeneration and cognitive decline occurs during the course of the disease and amylloid beta-peptide (Abeta) is believed to play a central role for the molecular pathogenesis of AD. The gamma-Secretase is a key enzyme involved in the processing of the beta-amyloid precursor protein into Abeta. Abeta accumulates in brain and forms plaques in AD brains. One of the mechanism behind neurodegenration in AD is apoptosis due to preservation of gamma secretase activity. Several proteins (presenilin1, presenilin 2, nicastrin, Aph-1 and Pen-2) interact with gamma secretase complex during apoptosis in neuronal cells to make active gamma secretase complexes in apoptotic cells.
Presenilin 2 is cleaved by caspase 3 to generate a 22 amino acid presenilin-loop peptide (PLP, 308-329 of presenilin 2) in cells undergoing apoptosis. Recent studies have shown that PLP caused a rapid release of calcium stores form the endoplasmic reticulum and suggest that intracellular release of calcium homeostasis may be an important link to acceleration of apoptosis (2). PLP and presenilin 2 may be an important therapeutic too for cancer and degenerative diseases. It is suggested that Presenilin 2 binds to InsP3 pathway. Numerous mutations in the presenilin 1 and 2 are known to cause early-onset familial Alzheimer’s disease (FAD). These mutations are known to alter the gamma-secretase cleavage of the amyloid precursor protein (APP), resulting in increased ratio of Abeta42/Abeta40 and accelerated amyloid plaque pathology in transgenic mouse models. Presenelin 2 is a 447 amino acid membrane bound protein with 8 putative TMD. It is believed to be the catalytic domain of gamma secretase complex that catalyzes the intramembrane cleavage of integral membraneproteins such as Notch receptors and beta amyloid precursor protein. Other functions include intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Some regulatory proteins associated with Resenelin are Nicastrin, NTF, CTF, APH1/2and PEN2. It also interacts with other proteins such as Notch1, cadherin 1, plakophilin 4, dock 3, catenin, HERPUD1, FLNA and FLNB.
The PSEN2-selective antibodies were generated against unique antigenic sequences form near N-terminal peptides for the presenilin 2 gene. The antibodies to PSEN 2 are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc., will also provide limited quantities of antigenic blocking peptides for PSEN-201AP. Antibodies to the Presenelin 1 (PSEN-101AP and PSEN-112AP) protein are also available from FabGennix International Inc. FabGennix Inc. will also conjugate antibodies with secondary enzymes (alk-Pase or HRP) or fluorescent probes upon request at a nominal cost.
For research use only, not for diagnostic or therapeutic use.
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