Per1 like domain containing protein
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| Per1-101AP | Per1 N-terminal antibodies | Rabbit | AP | h | 100.0 ug | 150-500 ul |
$245.00
|
| Per1-112AP | Per 1 mid-region antibodies | Rabbit | AP | h | 100.0 ug | 150-500 ul |
$245.00
|
| Per1-121AP | Per1 mid-region antibodies | Rabbit | AP | h | 100.0 ug | 150-500 ul |
$245.00
|
| Per1-131AP | Per1 C-terminal antibodies | Rabbit | AP | h, r, m, monk | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-Per100 | FITC-conjugated N-terminal antibodies | Rabbit | FITC-AP | h | 100.0 ug | 150-500 ul |
$350.00
|
| FITC-Per110 | FITC-conjugated mid-region antibodies | Rabbit | FITC-AP | h | 100.0 ug | 150-500 ul |
$350.00
|
| FITC-Per120 | FITC-conjugated mid-region antibodies | Rabbit | FITC-AP | h | 100.0 ug | 150-500 ul |
$350.00
|
| FITC-Per130 | FITC-conjugated C-terminal antibodies | Rabbit | FITC-AP | r, m, h, monk | 100.0 ug | 150-500 ul |
$350.00
|
| P-Per1-100 | N-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-Per1-110 | Mid-region antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-Per1-120 | Mid-region antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-Per1-130 | C-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-Per1 | WB positive control for Per1 | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
Certain loci on human chromosome 17q12 are frequently amplified in various types of cancers. One of such loci is PP1R1B-ERBB2-GRB7 which is greatly amplified in gastric and breast cancer. Search of other genes that reside close to this recombination hot spot or “fragile loci” led to discovery of several genes, one of these genes is a new theoretical protein MGC9753 is localized on chromosome 17 at cytogenetic location of 17q21.2. The detailed analyses of the amplicon structure in 330 breast tumors samples revealed a 280 kb common region of amplification that contains 10 genes that include 8 known genes. A highly significant association between amplification and expression levels was observed for 6 genes including ERBB2 and 2 uncharacterized hypothetical proteins, MGC9753 and MGC14832 in breast carcinoma and human gastric cancer samples (1, 2).
Per1 is involved in the lipid remodeling steps of GPI-anchor maturation.Glycosylphoshatidylinositol (GPI) anchors are remodeled during their transport to the cell surface. This remodeling involves interaction of newly synthesized proteins with GPI anchors consisting of diacylglycerol with conventional C16 and C18 fatty acids. The mature GPI-anchored proteins contain C26:0 fatty acids in the sn-2 position. This exchange of fatty acids and remodeling of GPI anchor require Per1 protein (3). The activity of Per1 is also required for activation of phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Per1is located on human chromosome 17q12 and is in the amplicon cluster consist of PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 with in the 120 kb region locus on human chromosome 17q12. Per1 like domain containing protein 1 9Per1) is a 7 transmembrane receptor with an extracellular six-cystein domain (3). The human and mouse Per 1 protein is a 320 amino acid 7-TMDS protein with 8 exons exhibiting 90.6% total amino acid identity with human CAB2 aberrant protein, which lacked the 3rd trans membrane domain due to a frame shift mutation within the ORF.
The Per1 (MGC9753-selective) antibodies were generated in rabbits against synthetic N, mid-regions and C-terminal peptides that are unique to Per1 like domain containing protein 1 (MGC9753) protein. FabGennix Inc. has generated specific rabbit anti-Per1 polyclonal mono-epitope-specific antibodies utilizing linear or cyclic peptide methodology. These antibodies have been characterized for cross-reactivity with other members of the amplicon related proteins. FabGennix Inc. has produced antibodies to multiple epitopes of the same protein, to facilitate studies utilizing epitope analyses and other functional and interspecies assays. FabGennix Inc. also provides limited quantities of all antigenic blocking peptides for Per1 antibodies.
For research use only, not for diagnostic or therapeutic use.
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