Multidrug Resistance Protein 1
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| MRP1-101AP | MRP 1 antibodies | Rabbit | AP | r, m | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-MRP1 | FITC-conjugated antibodies | Rabbit | FITC-AP | r, m | 100.0 ug | 150-500 ul |
$350.00
|
| P-MRP1 | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-MRP1 | WB positive control for MRP 1 | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
Multidrug resistance protein 1 (MRP1) belongs to a family of MRP proteins. Components of the MRP family of proteins are known to mediate the ATP-dependent efflux of chemotherapeutic drugs from cancer cells (1). MRP1 is an integral membrane transport and efflux protein involved in the release of glutathione synthase during oxidative stress. It is also implicated in multidrug resistance of cancer cells; it is responsible for actively pumping out chemotherapeutic drugs from tumor cells (2). It is located at rat chromosome 10q11. It plays an important role in the transport of inflammatory factors during ocular inflammation (3). In skeletal muscles, it may play a role in statin-induced myopathy (4).
MRP1 was predominantly expressed in human brain derived endothelial cells and it played a major role in suppressing the entry of highly active anti-retroviral therapy (5). Since MRP1 was also highly expressed in tumor cells, their specific inhibition may be the key in developing treatments for cancer and HIV. Inhibition or down regulation of MRP1 caused a significant reduction in the export of sphingosine-1-phosphate, a potent inflammatory mediator, from mast cells (6). MRP1 is highly expressed in cancer cells. It is approximately a 184 kDa protein (1532 amino acids).
The MRP1-selective antibodies were generated against antigenic sequence near the near the N-terminal end of the protein. The antibodies to MRP1 are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc., will also provide limited quantities of antigenic blocking peptides for MRP1 antibodies. FabGennix International Inc. also carries antibodies related to neurodegenerative disorders, for a complete listing please visit www.Fabgennix.com. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at a reasonable cost.
For research use only, not for diagnostic or therapeutic use.
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