Toll-Receptor 10

Toll-like receptor 10 (TLR10) is a member of TLR family; it is located on human chromosome 4p14. TLR family recognizes pathogens and also plays an important role in the activation of innate immunity to fight infectious diseases that pose a major threat to the health and survival of human beings (1). In humans, TLR family comprises of 10 functioning receptors (TLR1-TLR10), each of which can be classified based on their subcellular distribution and also their known agonists (2). TLR 10 is expressed on the cell surface; however, it is the only remaining orphan receptor in the TLR family. TLR10’s ligand(s) have yet to be identified (3). Similar to other members of TLR family, it associates with MyD88, the common Toll IL-1 receptor domain adapter. TLR10 is known to form homodimers and also heterodimers with TLR1 and TLR2 (4).

Expression of TLR10 is highly restricted. It is expressed as a highly N-glycosylated protein detected in B cell lines, B cells from peripheral blood, and in plasmocytoid dendritic cells from tonsils (5). TLR10 was also found to be expressed in lungs. It has been suggested that TLR10 may play a role in the recognition of airborne pathogens or airborne allergies (6). Genetic variation in TLR10 was found to be associated with asthma. TLR10 may also be involved in the genetics of preterm birth. It was discovered that haplotypes of TLR10 were associated with preterm birth (7). TLR10 is approximately a 97.3kDa protein (811 amino acids).

The TLR10-selective antibodies were generated against purified Toll-like Receptor 10 protein. TLR10-antibodies are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc., will also provide limited quantities of antigenic blocking protein for TLR-1001AP antibody. Antibodies to TLR10 (TLR-1001AP) will label ~97.3kDa protein in Western blot positive control samples for TLR10 and several other tissues. FabGennix Inc. will also conjugate antibodies with secondary enzymes (alk-Pase or HRP) or fluorescent probes upon request at nominal cost.

For research use only, not for diagnostic or therapeutic use.