Pro-Brain natriuretic peptide
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| PBNP-101AP | PBNP antibodies | Rabbit | AP | r, m, h, monk | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-PBNP | FITC-conjugated antibodies | Rabbit | FITC-AP | r, m, h, monk | 100.0 ug | 150-500 ul |
$350.00
|
| P-PBNP | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-PBNP | WB positive control for PBNP | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
The family of natriuretic peptides comprise of several 22-53 amino acid peptides with vasoadilator and diuretic properties and play a pivotal role in cardiovascular homeostasis. The arterial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP) are serected as prohormones (Pro-ANP and Pro-BNP and their levels are significantly increases in non survival cardiacdysfunction patients (1). They are also useful as a laboratory markers for myocardial dysfunction and various other clinical conditions such as pulmonary thromboembolism, transient tachypnea, sepsis and stroke. The levels of these peptides may also differentiate between survival and non-survival acute sepsis. The human BNP gene is located on chromosome 1 and encodes the prohormone proBNP. The main stimulus for peptide synthesis and secretion is myocyte stretch. The cardiac myocytesare the major sosurce of ProBNP, cardiac fibroblasts also produce the ProBNP. The realease of BNP is under the control of several neurohormone. The biological effects include diuresis, vasodilatation, inhibition of renin and aldosterone production and of cardiac and vascular myocyte growth (2)
There has been growing interest in the use of serum B-type natriuretic peptide (BNP) and the N-terminal segment of its pro-hormone (NT-proBNP) as biomarkers for cardiac disease. Increased plasma concentrations of cardiac-derived B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (proBNP) are both associated with left ventricular dysfunction (3). BNP protects the heart from adverse consequences of overload by increasing natriuresis and diuresis, relaxing vascular smooth muscle, inhibiting the renin-angiotensin-aldosterone system, and by counteracting cardiac hypertrophy and fibrosis. Human cardiomyocytes synthesized BNP as a 108 amino aicd prohormone (proBNP), which is cleaved to 32-amino aicd BNP and the 76-residue N-terminal fragment(NT-proBNP). Serum levels of both fragments are good indicator of cardiac dysfunction, increased concentrations are strong predictors of recurring myocardial infarction, heart failure, and even death.
The ProANP protein is a approximately 18kDa (151 amino acids) protein. The Anti-ProANP-selective antibody was generated against a peptide from aa 104-123. The affinity purified mono-specific polyclonal antibody to ProANP strongly labels a 15-18 kDa protein in PC-PANP samples and in various tissues examined. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge. FabGennix Inc. also provides antibodies against other natriuretic peptides like proBNP and others. FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6). FabGennix, Inc., will also provide Western blot positive controls most of its antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigens/blocking peptides are also available. Please enquire for their availability before ordering.
For research use only, not for diagnostic or therapeutic use.
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