Cornichon
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| CORN-101AP | Cornichon antibodies | Rabbit | AP | r, h | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-CORN | FITC-conjugated antibodies | Rabbit | FITC-AP | r, h | 100.0 ug | 150-500 ul |
$350.00
|
| P-CORN | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-CORN | WB positive control for CORN | n/a | Protein | n/a | 0.0 ug | 150 ul |
$185.00
|
The ligand gated AMPA receptors are mainly responsible for fast excitatory synaptic transmission mediated by released of glutamate by presynaptic terminals. Upon activation the AMPA receptors provide a transitory post excitatory postsynaptic current that depolarizes the membrane and initiates downstream signal transduction process such as action potential and synaptic plasticity (1, 2). The AMPA receptors are tetrameric assemblies of alfa subunits that are encoded by Glutamate receptor (GluR) genes Glut 1-4 aznd their splice variants that constitutes the heteromerric channels that display wide range of gating kinetics and calcium permeabilities (3). In addition ot alfa subunits, the AMPA receptors are also modulated by trans-membrane AMPA receptor regulatory proteins (TARPs), such as gamma 2 and gamma 3 subunits that directly co-assemble with GluR via protein-protein interaction and affect the gating properties and pharmacology of the ion channel (3). The TARPS also influence the trafficking and ion channel densities on the synaptic membrane. Since only 30% of the GluR are associated with gamma2 gamma 3 TARPs, the two TARPS most abundantly expressed in rat brain it is speculated that native AMPA receptors further yet unknown proteins to make up the complex. The proteomics analyses of native AMPA receptors, followed by 2D SDS-PAGE and MS-analyses reveals that all 4 GluR associate with membrane bound cornichon homolog 2.
Cornichon (CORN) proteins are structurally related transmembrane proteins that have been studied in and Drosophila and yeast where they are involved in embryo polarization by TGF beta-related events. At least 4 mammalian CORN sequences have been identified. Human and drosophila CORN protein are localized in the ER and associate with processing and secretion of TGF beta proteins. CORN protein performs selective transport and maturation and early stages of T-cell activation (4, 5). CORN interacts with AREG immature precursors and with immature TGFA that is lacking full N-glycosylation but not with fully glycosylated form. CORN is a multi-pass ER membrane protein and it cycles between Golgi and ER. The CORN proteins are highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid and testis, spleen, peripheral blood lymphocytes and bone marrow.
The Anti-cornichon-selective antibodies were generated against an antigenic sequence near C-terminal end of the protein that is unique to human and rat CORN protein. The CORN-selective antibodies are affinity purified against immobilized antigen based affinity chromatography which yielded epitope-specific antibodies. The CORN antibodies label an approximately 18kDa protein in Western blot using Western blot positive control for human CORN (PC-CORN). Anti-CORN-selective antibodies can be conjugated to FITC or other fluorophores for direct application in IHC and confocal microscopy at a nominal charge. Limited quantities of Western blot positive controls for CORN (PC-CORN) and antigenic blocking peptide for CORN antibody are also available, please inquire availability before placing orders. FabGennix Inc. also provides antibodies to many different targets, for a complete listing please visit www.fabgennix.com. FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity.
For research use only, not for diagnostic or therapeutic use.
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