Saxophone
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| SAX-101AP | Saxophone N-terminal antibodies | Rabbit | AP | Drosophila Melanogaster | 100.0 ug | 200 ul |
$245.00
|
| SAX-112AP | Saxophone C-terminal antibodies | Rabbit | AP | Drosophila Melanogaster | 100.0 ug | 200 ul |
$245.00
|
| FITC-SAX100 | FITC-conjugated N-terminal antibodies | Rabbit | FITC-AP | Drosophila Melanogaster | 100.0 ug | 200 ul |
$350.00
|
| FITC-SAX110 | FITC-conjugated C-terminal antibodies | Rabbit | FITC-AP | Drosophila Melanogaster | 100.0 ug | 200 ul |
$350.00
|
| P-SAX100 | N-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-SAX110 | C-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-SAX | WB positive control for SAX | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
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F
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ruit fly (Drosophila melanogaster) ovaries contains two set of germline stem cells surrounded by a group of highly differentiated somatic cells that express genes for two phenotypes (hedgehog & wingless). The TGF beta super family member, decpentaplegic (dpp) or its homologue BMP2/4 is specifically required for maintenance and promote its cell division in the female germline (1, 2). The Signaling by TGF beta-related factors requires ligand-induced association between type I and type II transmembrane receptors that have endogenous serine/threonine kinases activity. In Drosophila, the saxophone (sax) and thick veins (tkv) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein (BMP) subgroup of TGF beta-type factors. Over expression or mutation in dpp suppress germline stem cell differentiation. Dpp actions are mediated by its receptor Saxophone. The Saxophone gene is expressed ubiquitously. The Saxophone gene also gives two products Brk43E and Berk25 and both gene products inter acts with TGF super family peptide ligands Dpp. Mutations that completely abolish Saxophone activity causes phenotype that are similar to partial or complete loss of activity of the dpp ligand. The saxophone products are also have serine threonine kinase activity responsible for phsosphorylation and activation of the ligands including pMAD, Screw (Scw), and short gastrulation protein (Sog).
The Anti-Saxophone-selective antibodies were generated against conserved sequences near the N-terminus and the C-terminal end of the protein that are unique to Saxophone protein. The Saxophone-selective antibodies are affinity purified against immobilized antigen based affinity chromatography which yielded epitope-specific antibodies. The Saxophone antibodies label a 61-65kDa protein in D. melanogaster extracts. Anti-Saxophone-selective antibodies are also available in affinity-purified form for confocal, Western blotting and immunocytochemical analyses. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge.
FabGennix Inc. also provides several antibodies against proteins that are involved Drosophila melanogaster research such as several Anti-PDE antibodies, Anti-Wishfulthinking, Anti-Baboon, Anti-Shadow, Anti-Shade, Anti-SARA anchor protein, Anti-Phantom and Anti-Punt protein. FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6). FabGennix, Inc., will also provide Western blot positive controls for most of these antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigens are also available. Please enquire for their availability before ordering.
For research use only, not for diagnostic or therapeutic use.
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