The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors (TNF), Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned and have shown significant advancement in its understanding of signaling pathways. In the last several years considerable advancement have been made regarding the signaling pathways activated by p75NTR and its potential biological functions. It is now known that P75NTR has surprisingly diverse effects, ranging from cell death to regulation of axon elongation. This diversity in its physiological effects can be explained by the complex formation of p75NTR with other receptors and multiple signaling molecules that interact with the intracellular domain of p75NTR (1). Neuronal survival, differentiation and mylination also involves p75NTR signaling via Trk receptor kinases. Identification of new ligands, cytosolic interacting partners, receptor cleavage products and coreceptors for the p75NTR led to greater understanding of p75NTR signaling (2).
Nerve growth factor (NGF) is synthesized by various structural and inflammatory cells and activates Tropomyosin-receptor kinase A (TrkA) and the p75NTR receptor, both belong to the “death receptor” family. One of the several diverse effects of p75NTR signaling is neuronal apoptosis that requires interaction of neurotrophin receptor interacting factor (NRIF) with c-Jun-N-terminal kinase (JNK) and p53 activation (3). The p75NTR has been characterized as a tumor suppressor in human prostate cancer. Administration of the p75NTR gene into subcutaneous PC-3 xenografts suppressed in a dose-dependent manner the growth of tumors (4). P75NTR has multiple functional domains including a NTRF and a C-terminal Death domain.
The Anti-p75NTR-selective antibodies were generated using unique peptides from near N-terminal portion of the p75NTR protein. The p75NTR-selective antibodies were affinity purified against immobilized antigen based affinity chromatography and are represented as pure IgG fractions stabilized in antibody stabilization buffer. The polyclonal antibodies strongly label a 76 kDa in PC-P75NTR samples. The P75NTR antibodies can be conjugated as HRP or alkaline conjugates for IHC, Confocal, WB analyses at nominal price. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge. FabGennix Inc. also provides antibodies against other diagnostic/neomarkers, the list of these antibodies can be obtained at www.FabGennix.com under Antibodies to diagnostic markers. Limited quantities of antigens are also available. Please enquire for their availability before ordering.
For research use only, not for diagnostic or therapeutic use.
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