EGF-Febulin like extracellular protein
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| EFP-101AP | EFEMP1 antibodies | Rabbit | AP | r, m, h, monk | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-EFP | FITC-conjugated antibodies | Rabbit | FITC-AP | r, m, h, monk | 100.0 ug | 150-500 ul |
$350.00
|
| P-EFT | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-EFT | WB positive control for EFEMP1 | n/a | Protein | n/a | 0.0 ug | 150 ul |
$185.00
|
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M
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alattia Leventinese (ML) and Doyne honeycomb retinal dystrophy (DHRD) refer to two autosomal dominant diseases characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium (RPE) (1). A single missense mutation (R345W) in the gene encoding the EGF-containing fibulin like extracellular matrix protein-1 (EFEMP1) has been described in both DHRD and MLVT syndromes and are now thought to represent a single entity (2). There are two EGF-containing fublin like extracelluar proteins have been characterized so namely, EFEMP1 and EFEMP2.
The EGF-containing fibulin like extracellular protein (EFEMP1) protein is approximately 65 kDa (495 amino acids) protein that is mainly expressed in RPEs. The EFEMP1 has multiple conserved domains in the middle of protein. The Anti-EFEMP1-selective antibody was generated against a conserved sequence near the C-terminal that is unique to EFEMP1 protein only. The polyclonal antibody strongly labels a 62 kDa protein in RPE cell extracts. Anti-EFEMP1-selective antibody is also available in affinity-purified form for confocal, Western blotting and immunocytochemical analyses. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge. FabGennix Inc. also provides antibodies against proteins that are involved in retinal degenerative diseases such as various Anti-PDE antibodies, Anti-MERTK, Anti-Orphan receptor G-75; Anti-Myocilin (TIGR), Anti-Bestrophin, Anti-ELVOL4 and a Usher syndrome specific Anti-USH2a antibody. FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6).
FabGennix, Inc., will also provide Western blot positive controls for most of these antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigens are also available. Please enquire for their availability before ordering.
For research use only, not for diagnostic or therapeutic use.
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