Receptor Tyrosine Kinase MERTK
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| MKT-101AP | MERTK N-terminal antibodies | Rabbit | AP | r, m, h, monk | 100.0 ug | 200 ul |
$245.00
|
| MKT-112AP | MERTK Mid-Region antibodies | Rabbit | AP | r, m, h, monk | 100.0 ug | 200 ul |
$245.00
|
| MKT-121AP | MERTK C-terminal antibodies | Rabbit | AP | r, m, h, monk | 100.0 ug | 200 ul |
$245.00
|
| FITC-MKT100 | FITC-Conjugated N-terminal antibodies | Rabbit | FITC-AP | r, m, h, monk | 100.0 ug | 200 ul |
$350.00
|
| FITC-MKT110 | FITC-Conjugated Mid-Region antibodies | Rabbit | FITC-AP | r, m, h, monk | 100.0 ug | 200 ul |
$350.00
|
| FITC-MKT120 | FITC-Conjugated C-terminal antibodies | Rabbit | FITC-AP | r, m, h, monk | 100.0 ug | 200 ul |
$350.00
|
| P-MKT100 | N-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-MKT110 | Mid-Region antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| P-MKT120 | C-terminal antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-MKT | WB positive control for MERTK | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
In vertebrate, the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors (1). Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration (2) resulting in to retinitis pigmentosa.
The receptor tyrosine kinase MERTK protein is a approximately 170-175 kDa (994 amino acids) protein expressed in long evans rat testis and RPEs. The MERTK protein has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites. The Anti- MERTK-selective antibody was generated against a conserved sequence near the N-terminal that is unique to MERTK protein only. The polyclonal antibody strongly labels a 174kDa protein in RPE cell extracts. Anti-MERTK-selective antibody is also available in affinity-purified form for confocal, Western blotting and immunocytochemical analyses. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge. FabGennix Inc. also provides antibodies against proteins that are involved in retinal degenerative diseases such as various Anti-PDE antibodies, Anti-EFEMP1, Anti-Orphan receptor G-75; Anti-Myocilin (TIGR), Anti-Bestrophin, Anti-ELVOL4 and a Usher syndrome specific Anti-USH2a antibody. FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6).
FabGennix, Inc., will also provide Western blot positive controls for most of these antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigens are also available. Please enquire for their availability before ordering.
For research use only, not for diagnostic or therapeutic use.
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