La Ribonucleoprotein domain family member 7

In eukaryotic cells, RNA-binding proteins (RBPs) contribute to gene expression by regulating the form, abundance, and stability of both coding and non-coding RNAs. In the vertebrate brain, RBPs account for many distinctive features of RNA processing such as activity-dependent transcript localization and localized protein synthesis.  There are 380 putative RBPs in the mouse genome that are identified, at least 323 of them are expressed in embryonic age 13.5 and post natal age 0 when critical signals are required for development of major structural differentiation. Sixteen out of 323 genes are neuronal specific and majority of these genes (221 out of 323) exhibit regionally restricted expression (1). The initiation of human embryo implantation process resulted in expression of a large number of RBPs that are derived from extra-embryonic cells.   These genes are under tight control of expression during development.  

        One of these several genes is La riboneucleoprotein domain family member 7 (LaRP7). These proteins are expressed in embryonic ovary testis and brain. LaRP is expressed in testis of adult sex-reversed mice which lack the germ cell and therefore represent a meiosis-specific gene. It is part of the mouse multigene family, member of which are mapped to a single region of the X-chromosome. The LaRP7 contains several function domains including a domain in the RNA binding Lupus La protein of unknown function, a RNA recognition motif (RRM) which is diagnostic to the RNA binding protein and a LHP1 domain which is binding site for small RNA-RNA polymerase III transcript stabilizing protein and related La-motif-containing proteins involved in translation.  The HDCMA18P is similar to LARP family member 7 protein from amino acid 382-595, it represents only the lower 50% of LARP7 protein of various variants.       

The LARP7/HDCMA-selective antibodies were generated using a peptide from the LARP family member 7 protein. The antibodies LARP7 are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc., will also provide limited quantities of antigenic blocking peptides for LARP7 antibodies. FabGennix International Inc. also carries a number of antibodies to RNA biding protein, for a complete listing visit www.FabGennix.com. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at a reasonable cost.

For research use only, not for diagnostic or therapeutic use.