human nuclear matrix proteins
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| hNMP-101AP | hNMP antibodies | Rabbit | AP | r, m, h | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-hNMP | FITC-conjugated antibodies | Rabbit | FITC-AP | r, m, h | 100.0 ug | 150-500 ul |
$350.00
|
| P-hNMP | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-hNMP | WB positive control for hNMP | n/a | Prtoein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
The human nuclear matrix proteins ((hNMPs) are largely responsible for protein assembly by reassembling and potential filament forming capability (1). The hNMP200 is one of the members of about 350 proteins that are involved in chaperoning and reassembly of proteins in nuclear matrix proteins. The hNMP200 is a novel 56 kDa nuclear protein that is homologues to S.cerevidiae protein PRP19, which is an accessory, but essential factor for pre mRNA processing. The hNMP200 gene is assigned to chromosome 11q22 and in mainly confined to nucleoplasmic region. An hNMP200 is a novel 56 kDa nuclear proteins that binds to double stranded DNA, but not the single stranded DNA in a sequence non-specific manner. The hNMP200 is homologues to plant, metazoans and yeast protein pre mRNA processing protein 19 (prp19) that is an assessor, but essential factor for pre mRNA processing. The hNMP 200 sequence contained 5 consensus WD repeats, characteristics of participatory and regulatory function in larger protein assemblies. The hNMP200/hPSO4 expression was noted ubiquitously in a variety of cells and was confined to nuclear region. The hNMP/hPSO4 is expressed manly in nucleolus of cells in the interphase cycle. During cell division hNMP 200 became irregularly distributed in prophase, sparing regions of condensing chromatin. In anaphase it was concentrated in the spindle midzone (3). The hNMP/hPSO4 being a component of the nuclear framework, it may provide structural support for components of the RNA-processing machinery, thereby also modulating splicing activities.
The role of hNMP/hPSO4 in double strand breaks (DSBs) is just emerging (2). hNMP/hPso4 protein is induced 15- to 30-fold in cells by gamma radiation and chemical mutagens but not by UV treatment. Loss of hPso4 expression induced by siRNA results in accumulation of DSBs, apoptosis, and decreased cell survival after DNA damage. We conclude that hPso4 plays a major and previously undefined role in mammalian DNA DSB repair.
The hNMP/hPSO4-selective antibodies were generated against peptide form unique regions of the hNMP/hPSO4 protein. FabGennix Inc. has generated epitope specific rabbit anti-hNMP/hPSO4 polyclonal antibodies utilizing linear and cyclic peptide sequences. These antibodies have been fully characterized for cross reactivity with other members of the bone morphogenetic proteins and other proteins. Limited quantities of the antigenic blocking peptide for hNMP/hPSO4 antibodies is also available.
For research use only, not for diagnostic or therapeutic use.
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