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Eukaryotic protein synthesis initiation factor

Catalog# Product Description Host Species Nature Cross reactivity Quantity Volume Price
eIF4E-101AP eIF4E antibodies Rabbit AP r, m, h, c, monk 100.0 ug 150-500 ul $245.00
FITC-eIF4E FITC-conjugated antibodies Rabbit FITC-AP r, m, h, c, monk 100.0 ug 150-500 ul $350.00
P-eIF4E Antigenic blocking peptide n/a Synthetic peptide n/a 250.0 ug 100 ul $125.00
PC-eIF4E WB positive control for eIF4E n/a Protein in ready-to-use buffer n/a 0.0 ug 150 ul $185.00
The capped-mRNA binding protein, eukaryotic protein synthesis Initiation factor 4E (eIF-4E) is directly involved in the initiation of protein synthesis in eukaryotic cells. It has been shown that eIF-4E phosphorylation at serines by insulin dependent mechanism coincides with increased protein synthesis in various tissues (1-3). Numerous other extra cellular stimuli also phosphorylate eIF-4E via protein kinase C and insulin-stimulated protamine kinases (cPK). Conversely, dephosphorylation of eIF-4E results in decrease protein synthesis rate. It has been shown that cPK and PKC phosphorylates eIF-4E at Serine209 and threonine210. The phosphorylation of serine 209 activates the eIF-4E protein synthesis activity, protein phosphatase 2A (PP2A), a major cytoplasmic serine-, threonine-phosphatase preferentially dephosphorylates insulin-dependent phosphorylated eIF-4E factor at threonine 210. 
 
The eIF-4E selective antibodies were generated against purified human recombinant eIF-4E protein. The antibodies eIF-4E are affinity purified over immobilized antigen based chromatography. The purified antibodies are stabilized in antibody stabilization buffer containing preservatives. FabGennix Int. Inc., will also provide purified human recombinant eukaryotic initiation factor 4E, please enquire about pricing and availability. Other related antibodies that are carried by FabGennix Int. Inc. include p21 activated protein kinase (p65pak), Anti-auto-activated protein kinase, Anti-protein phosphatase 2A inhibitor protein. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at a reasonable cost.    

For research use only, not for diagnostic or therapeutic use.

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Eukaryotic protein synthesis initiation factor

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