Pro-Arterial Natriuretic peptide
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| PANP-101AP | PANP antibodies | Rabbit | AP | h, r, m, monk | 100.0 ug | 150-500 ul |
$245.00
|
| FITC-PANP | FITC-conjugated antibodies | Rabbit | FITC-AP | h, r, m, monk | 100.0 ug | 150-500 ul |
$350.00
|
| P-PANP | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100 ul |
$125.00
|
| PC-PANP | WB positive control for PANP | n/a | Protein in ready-to-use buffer | n/a | 0.0 ug | 150 ul |
$185.00
|
The family of natriuretic peptides comprise of several 22-53 amino acid petides with vasoadilator and diuretic properties and play a pivotal role in cardiovascular homeostasis. So far we have five natriuretic peptides known ANP, urodilin, ANP, CNP and DNP. The prohormones for ANP, BNP and CNP are encoded by different genes. The arterial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP) are serected as prohormones (Pro-ANP and Pro-BNP) and their levels are significantly increases in non survival cardiacdysfunction patients (1). They are also useful as a laboratory markers for myocardial dysfunction and various other clinical conditions such as pulmonary thrombo embolism, transient tachypnea, sepsis and stroke. The levels of these peptides may also differentiate between survival and non-survival acute sepsis. The Pro ANP is stored in the cells and are released upon stretch from artria into circulation. The rate limiting protease, corin, a trans-membrane serine protease converts Pro-ANP in to ANP for immediate release in to circulation. The release of ANP cuases an increase in cGMP in the cells by acting on 3 types of ANP receptors (ANPA, ANPB and ANPC).
In situ, ANP is phosphorylated by cAMP-dependent Kinase at ser-104 however, only a subpopulation of the ANP molecules are regulated by this mechanism. The pro-ANP gene is a 151 amino acid soluble protein with a low complexity amino terminal region. The proANP (15 kDa) is cleaved by cardiomyocytes to 3kDa active ANP. There is a significant homology in the primary amino acid sequence and of physiological effects of ANP across different species.
The ProANP protein is a approximately 18kDa (151 amino acids) protein. The Anti-ProANP-selective antibody was generated against a peptide from aa 104-123. The affinity purified mono-specific polyclonal antibody to ProANP strongly labels a 15-18 kDa protein in PC-PANP samples and in various tissues examined. FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge. FabGennix Inc. also provides antibodies against other natriuretic peptides like proBNP and others. FabGennix Inc employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6). FabGennix, Inc., will also provide Western blot positive controls most of its antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigens/blocking peptides are also available. Please enquire for their availability before ordering.
For research use only, not for diagnostic or therapeutic use.
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