Ephrin 2 Receptor
| Catalog# | Product Description | Host Species | Nature | Cross reactivity | Quantity | Volume | Price |
|---|---|---|---|---|---|---|---|
| EphR-201AP | EphR2 antibodies | Rabbit | Affinity purified antibody | h | 100.0 ug | 150-500ul |
$245.00
|
| FITC-EphR2 | FITC-conjugated antibody | Rabbit | FITC-conjugated antibodies | h | 100.0 ug | 150-500ul |
$245.00
|
| P-EphR2 | Antigenic blocking peptide | n/a | Synthetic peptide | n/a | 250.0 ug | 100ul |
$125.00
|
| PC-EphR2 | WB positive control for EphR2 | n/a | Protein in ready-to-use bufer | n/a | 0.0 ug | 150ul |
$185.00
|
The membrane bound Ephrins are ligands for Ephrin receptor tyrosine kinases that regulate several physiological functions including long-term potentiation, cell positioning, CNS development and axonal path finding and mitogenesis etc. Ephrins molecules exhibit the ability to send bidirectional signals following ligand-receptor interactions resulting from cell-cell contacts. Activation of Eph receptors are also shown to regulate transduction pathways important in cell cycle control as well as cell death. There are at least 4 different kinds of Ephrin B receptors are cloned (Ephrin B1R-Ephrin B4R). EphB receptor tyrosine kinases and ephrin-B ligands also regulate several types of cell-cell interactions during brain development, generally by modulating the cytoskeleton. EphB/ephrinB genes are expressed in the developing neural tube of early mouse embryos with distinct overlapping expression in the ventral midbrain. The positioning of cells within the stem cell niche in the intestinal epithelium is controlled by B subclass ephrins through their interaction with EphB receptors. Ephrin 3 ligands are also known as guidance molecule as they are mainly responsible for positioning and directing the cell migration along the villus-crypt axis in intestine. Ephrin 3 by interacting with ephrin B3 receptors in conjunction with Wnt proteins signals and promotes cell cycle re-entry of proginator cells and accounts for 50% of the mitogenic activity. The Ephrin B receptors are the key coordinators of the intestinal stem cell niche (1).
Ephrin B3 ligands are highly expressed in the mossy fibers axons and terminals and the Ephrins B3 receptors are expressed on post-synaptic neurons. Ephrin-B3 promotes adhesion of hippocampal neurons to the ligand-expressing substrates in vitro, and the loss of the receptor or EphB2 abrogates the effects of ephrin-B3 (2). The function of Ephrins in the immune system has not been well studied, although some Ephrins and Ephrin receptors are expressed at high levels on certain leukocytes. EFNB3 and its cognate receptors are expressed in peripheral T cells and monocytes/macrophages. The role of EphR2 and EphR4 in angiogenesis and formation of arteries and veins come form findings that EphR2 marks arteries but not veins and conversely, the EphR4 labels exclusively the veins (3). .
The EphR2-selective antibodies were generated against highly antigenic epitopes unique to EphR2 receptor tyrosine kinase that are not present on other Ephrin B Receptors. The antibodies to EphR2 receptors are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. FabGennix Int. Inc., will also provide limited quantities of antigenic blocking peptides for EphR-201AP antibodies. FabGennix International Inc. also carries antibodies that are related to other Ephrin Receptor tyrosine kinase targets and BMP proteins, a complete list of all the antibodies please visit www. FabGennix.com. FabGennix Inc. will conjugate antibodies with enzymes or fluorescent probes as custom service upon request at a reasonable cost.
For research use only, not for diagnostic or therapeutic use.
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